Drug Information

Drug General Information
Drug ID
D0R1JI
Former ID
DPR000101
Drug Name
Rottlerin
Synonyms
Kamalin; Mallotoxin; R 5648; BMK1-F10; (E)-1-(6-((3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl)-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one; (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one; 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenyl-propenone; 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one; 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Preclinical [536923], [539687]
Structure
Download
2D MOL

3D MOL
Formula
C30H28O8
InChI
InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
InChIKey
DEZFNHCVIZBHBI-ZHACJKMWSA-N
CAS Number
CAS 82-08-6
PubChem Compound ID
5281847
PubChem Substance ID
12904, 105770, 399681, 3153150, 8616811, 14762702, 17405610, 24278679, 26752221, 26752222, 26759460, 29204544, 39315440, 46391355, 46499867, 47440005, 47515095, 47662030, 47885185, 48034855, 48258970, 48483334, 49863415, 50104906, 50104907, 50104908, 50104909, 53521727, 53778158, 53789304, 57358417, 71822747, 74381038, 85789037, 85789464, 90340883, 91722237, 92303370, 92310076, 99300988, 99302508, 103210193, 104018897, 104051642, 109816921, 113856047, 121361810, 124557942, 124634337, 124887042
Target and Pathway
Target(s) Protein kinase C Target Info Inhibitor [536923]
References
Ref 536923Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
Ref 539687(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2611).
Ref 536923Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.

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