Drug General Information
Drug ID	D0R1VL
Former ID	DIB008949
Drug Name	BIBN-99
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[545083]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Formula	C31H42ClN5O3
Canonical SMILES	n1(c2c(c(=O)[nH]c3c1nccc3)cc(cc2)Cl)C(=O)CN1CCC(CC1)CCC<br />N(C(=O)C(CCC)(C)C)CC
CAS Number	CAS 145301-48-0
PubChem Compound ID	132712
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M2	Target Info	Modulator	[533931]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	G alpha (i) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545083	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002066)
Ref 533931	Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.