Drug General Information
Drug ID	D0R1YL
Former ID	DNC001012
Drug Name	NGX-267
Drug Type	Small molecular drug
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Phase 2	[522264]
Structure		Download 2D MOL 3D MOL
Formula	C10H18N2OS
Canonical SMILES	CCC1C(=O)NC2(S1)CCN(CC2)C
InChI	1S/C10H18N2OS/c1-3-8-9(13)11-10(14-8)4-6-12(2)7-5-10/h8H,3-7H2,1-2H3,(H,11,13)/t8-/m0/s1
InChIKey	PHOZOHFUXHPOCK-QMMMGPOBSA-N
CAS Number	CAS 91374-20-8
PubChem Compound ID	10013505
PubChem Substance ID	14993894, 22444724, 26755730, 44105600, 79055724, 135199335, 135694260, 139119569, 162262810, 162545880, 164841395, 198969528, 204433810, 223854773, 229649349, 245887492, 252815869
SuperDrug ATC ID	N04BC04
SuperDrug CAS ID	cas=091374219
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M1	Target Info	Agonist	[537030]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522264	ClinicalTrials.gov (NCT00637793) Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome. U.S. National Institutes of Health.
Ref 537030	Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. Epub 2009 Jan 11.

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