Drug General Information
Drug ID	D0R2DP
Former ID	DIB021229
Drug Name	XAP044
Synonyms	7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[532694]
Structure		Download 2D MOL
Formula	C15H9IO4
InChI	InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChIKey	XXZKJJYWINSUMJ-UHFFFAOYSA-N
PubChem Compound ID	5428913
PubChem Substance ID	4268985, 11679814, 25634129, 39427513, 47905708, 53161898, 71999682, 88877215, 113935882, 117615440, 164245385, 166218704, 223332977, 241493833, 252158718, 252166746
Target and Pathway
Target(s)	Metabotropic glutamate receptor 7	Target Info	Modulator (allosteric modulator)	[532694]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 532694	Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87.
Ref 532694	Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87.

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