Drug Information

Drug General Information
Drug ID
D0R2WK
Former ID
DNC013651
Drug Name
NVP-TAE684
Drug Type
Small molecular drug
Indication Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86] Investigative [541053]
Structure
Download
2D MOL

3D MOL
Formula
C30H40ClN7O3S
InChI
InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
InChIKey
QQWUGDVOUVUTOY-UHFFFAOYSA-N
PubChem Compound ID
16038120
PubChem Substance ID
24420733, 26586860, 41797425, 99205953, 99436912, 103583785, 103904598, 104099207, 109692872, 124757006, 124947877, 125163811, 125434026, 126582049, 126738823, 131480685, 134350856, 134964417, 135642892, 135686038, 135686039, 135686060, 135686061, 135697739, 135727576, 136340215, 136367306, 136367856, 138475841, 143499019, 144116303, 152239917, 152258113, 152344265, 160646952, 162011368, 162037441, 162202654, 172650400, 174006515, 174530590, 177748736, 178102340, 180190843, 185998799, 187071979, 188899497, 198959115, 223680889, 223705047
Target and Pathway
Target(s) Insulin receptor Target Info Inhibitor [528588]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathway
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transport
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recycling
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK Signaling
References
Ref 541053(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5714).
Ref 528588Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. Epub 2006 Dec 21.Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.