Drug Information
Drug General Information | |||||
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Drug ID |
D0R3JB
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Former ID |
DAP000057
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Drug Name |
Mitoxantrone
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Synonyms |
DHAD; DHAQ; Dihydroxyanthraquinone; MIX; Misostol; Mitoxanthrone; Mitoxantron; Mitoxantrona; Mitoxantronum; Mitozantrone; DHAQ HCl; Mitoxantrone [INN]; Mitozantrone hydrochloride; Mitoxantrone 2HCl; Liposome Encapsulated Mitoxantrone (LEM); Misostol (TN); Mitoxantrona [INN-Spanish]; Mitoxantrone (INN); Mitoxantrone (free base); Mitoxantronum [INN-Latin]; Novantrone (TN); AN-584/42007670; Novantrone(R) (mitoxantrone for injection concentrate); DHAQ (*Diacetate salt*); MITOXANTRONE, Mitoxantrone Hydrochloride, Mitoxantrone dihydrochloride, MITOXANTHRONE HYDROCHLORIDE; MITOXANTRONE, 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)ANTHRA-9,10-QUINONE; 1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone; 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE; 1,4-Dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedione; 1,4-Dihydroxy-5,8-bis(5-hydroxy-3-azapentylamino)anthrachinon; 1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra-9,10-quinone; 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione; 5,8-Bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone; 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-(9CI)
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Drug Type |
Small molecular drug
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Therapeutic Class |
Analgesics
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Company |
Serono
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Structure |
Download2D MOL |
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Formula |
C22H28N4O6
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InChI |
InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
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InChIKey |
KKZJGLLVHKMTCM-UHFFFAOYSA-N
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CAS Number |
CAS 65271-80-9
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PubChem Compound ID | |||||
PubChem Substance ID |
13376, 142727, 600874, 4873554, 7980008, 8152633, 11111482, 11111483, 11335691, 11360930, 11364549, 11367111, 11369673, 11372759, 11374669, 11377835, 11406669, 11406928, 11461902, 11466413, 11467533, 11484492, 11486226, 11488724, 11491405, 11492681, 11495469, 14710338, 14857298, 15047380, 17417295, 24769895, 29223317, 46394146, 46504608, 47216744, 47365147, 47440212, 47440213, 47515285, 47662243, 47736437, 48035072, 48035073, 48184960, 49698959, 49870599, 50111146, 53790842, 56352855
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ChEBI ID |
ChEBI:50729
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SuperDrug ATC ID |
L01DB07
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SuperDrug CAS ID |
cas=065271809
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Drug Resistance Mutation (DRM) | |||||
DRM | DRM Info | ||||
Target and Pathway | |||||
Target(s) | DNA topoisomerase II | Target Info | Modulator | [534547] | |
References | |||||
Ref 536803 | Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis. J Neurol Sci. 2008 Oct 15;273(1-2):144-7. Epub 2008 Aug 6. | ||||
Ref 542259 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7242). |
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