Drug Information
Drug General Information | |||||
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Drug ID |
D0R8FM
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Former ID |
DIB011790
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Drug Name |
Ebrotidine
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Synonyms |
Ebrocit; FI-3542
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Drug Type |
Small molecular drug
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Indication | Duodenal ulcers [ICD10:K25-K27] | Withdrawn from market | [1] | ||
Company |
Ferrer Internacional SA
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Structure |
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Download2D MOL |
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Formula |
C14H17BrN6O2S3
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Canonical SMILES |
S(=O)(=O)(N/C=N/CCSCc1nc(NC(=N)N)sc1)c1ccc(cc1)Br
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CAS Number |
CAS 100981-43-9
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H2 receptor | Target Info | Modulator | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (s) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001139) | ||||
REF 2 | Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46. | ||||
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