Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R8FM
|
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| Former ID |
DIB011790
|
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| Drug Name |
Ebrotidine
|
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| Synonyms |
Ebrocit; FI-3542
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| Drug Type |
Small molecular drug
|
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| Indication | Duodenal ulcers [ICD10:K25-K27] | Withdrawn from market | [1] | ||
| Company |
Ferrer Internacional SA
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| Structure |
|
Download2D MOL |
|||
| Formula |
C14H17BrN6O2S3
|
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| Canonical SMILES |
S(=O)(=O)(N/C=N/CCSCc1nc(NC(=N)N)sc1)c1ccc(cc1)Br
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| CAS Number |
CAS 100981-43-9
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001139) | ||||
| REF 2 | Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46. | ||||
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