Drug Information

Drug General Information
Drug ID
D0R8KA
Former ID
DIB020780
Drug Name
pyrrolopyrimidine 48
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531793], [541066]
Structure
Download
2D MOL
Formula
C23H23N5O
InChI
InChI=1S/C23H23N5O/c1-2-6-18(7-3-1)16-28-15-11-20-22(28)25-17-26-23(20)29-19-9-13-27(14-10-19)21-8-4-5-12-24-21/h1-8,11-12,15,17,19H,9-10,13-14,16H2
InChIKey
ZMRCFNOIVYNNGH-UHFFFAOYSA-N
PubChem Compound ID
73755149
PubChem Substance ID
178102357
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.7 Target Info Blocker (channel blocker) [531793]
Reactome Interaction between L1 and Ankyrins
References
Ref 531793Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2052-62.
Ref 541066(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5731).
Ref 531793Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2052-62.

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