Drug Information

Drug General Information
Drug ID
D0R9HI
Former ID
DCL000391
Drug Name
SB-742457
Synonyms
GSK 742457; SB 742457; GSK-742457; 3-(benzenesulfonyl)-8-piperazin-1-yl-quinoline
Drug Type
Small molecular drug
Indication Alzheimer disease; Dementia [ICD9: 290-294, 331.0; ICD10:F01-F07, G30] Phase 2 [547877]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C19H19N3O2S
Canonical SMILES
C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4
InChI
1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
InChIKey
JJZFWROHYSMCMU-UHFFFAOYSA-N
PubChem Compound ID
11256720
PubChem Substance ID
16342129, 23432880, 42336247, 57304406, 80580213, 103756096, 104152994, 125646223, 126671677, 131320697, 135261679, 137099831, 141802492, 162009827, 162210546, 162223698, 162567130, 163620787, 163686112, 174529998, 174538911, 186014821, 187072839, 188932818, 196409663, 198952878, 218903267, 223675869, 223947486, 227869399, 242059992, 245722800, 251910589, 251963241, 251971156, 252450570
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [544323], [550963]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 547877Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020107)
Ref 5443235-HT6 receptors and Alzheimer's disease. Alzheimers Res Ther. 2013; 5(2): 15.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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