Drug General Information
Drug ID
D0R9VV
Former ID
DNC008085
Drug Name
CHLOROCYCLINONE C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529182]
Structure
Download
2D MOL

3D MOL

Formula
C26H21ClO10
Canonical SMILES
CC1=C(C(=C2C(=C1)C=C(C3=C2C(=O)C4=CC(=C(C(=C4C3=O)O)C(C<br />)OC(=O)CO)C(=O)OC)O)OC)Cl
InChI
1S/C26H21ClO10/c1-9-5-11-6-14(29)19-20(17(11)25(35-3)21(9)27)22(31)12-7-13(26(34)36-4)16(10(2)37-15(30)8-28)23(32)18(12)24(19)33/h5-7,10,28-29,32H,8H2,1-4H3
InChIKey
LMNHPKWXMIGBEL-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) mRNA of PPAR-gamma Target Info Inhibitor [529182]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 529182J Nat Prod. 2007 Dec;70(12):1934-8. Epub 2007 Nov 29.Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation.
Ref 529182J Nat Prod. 2007 Dec;70(12):1934-8. Epub 2007 Nov 29.Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation.

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