Drug Information

Drug General Information
Drug ID
D0R9ZY
Former ID
DIB018588
Drug Name
3-azageranylgeranyl diphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540177]
Structure
Download
2D MOL
Formula
C19H37NO7P2
InChI
InChI=1S/C19H37NO7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13H,6-8,10,12,14-16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+
InChIKey
OEMBPHBKZPOPBN-NWLVNBMCSA-N
PubChem Compound ID
447278
PubChem Substance ID
841144, 7888907, 15331130, 24561725, 36889477, 57404799, 57654752, 77550110, 99444651, 103265835, 104007638, 104637772, 111978442, 135649733, 144099722, 144223675, 144223677, 160969234
Target and Pathway
Target(s) Geranyltranstransferase Target Info Inhibitor [526333]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
Geranylgeranyldiphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
References
Ref 540177(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3199).
Ref 526333Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem. 2002 May 23;45(11):2185-96.

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