| Drug General Information |
| Drug ID |
D0RB0D
|
| Former ID |
DNC010066
|
| Drug Name |
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H8O5
|
| Canonical SMILES |
COC1=CC2=C(C=C1)C(=CC(=O)O2)C(=O)O
|
| InChI |
1S/C11H8O5/c1-15-6-2-3-7-8(11(13)14)5-10(12)16-9(7)4-6/h2-5H,1H3,(H,13,14)
|
| InChIKey |
IHHLDCASADSHEG-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase I |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
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Pathway Interaction Database
|
C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
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PathWhiz Pathway
|
Gastric Acid Production
|
|
Reactome
|
Erythrocytes take up carbon dioxide and release oxygen
|
|
Erythrocytes take up oxygen and release carbon dioxide
|
|
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
|
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WikiPathways
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Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
|
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
|
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBase
|
| References |
| REF 1 | J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. |
|---|
