| Drug General Information |
| Drug ID |
D0S0NX
|
| Former ID |
DIB005398
|
| Drug Name |
Peginterferon beta
|
| Synonyms |
AZ-01; AZ-60; Jak2 inhibitors (myeloproliferative disorders); Jak2 inhibitors (myeloproliferative disorders), AstraZeneca
|
| Indication |
Multiple scierosis [ICD9: 340; ICD10:G35]
|
Phase 1 |
[1]
|
|---|
| Company |
Allozyne
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
c1(nc(cc(n1)N1CCOCC1)Nc1sc(cn1)C)N[C@@H](C)c1ccc(cn1)F
|
| Target and Pathway |
| Target(s) |
Tyrosine-protein kinase JAK2 |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
Chemokine signaling pathway
|
|
PI3K-Akt signaling pathway
|
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Signaling pathways regulating pluripotency of stem cells
|
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Jak-STAT signaling pathway
|
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Cholinergic synapse
|
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Prolactin signaling pathway
|
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Adipocytokine signaling pathway
|
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Leishmaniasis
|
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Toxoplasmosis
|
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Tuberculosis
|
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Measles
|
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Influenza A
|
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Herpes simplex infection
|
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PANTHER Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
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Interferon-gamma signaling pathway
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JAK/STAT signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
|
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CCKR signaling map ST
|
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Pathway Interaction Database
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Endothelins
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ErbB4 signaling events
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GMCSF-mediated signaling events
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IL4-mediated signaling events
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IL27-mediated signaling events
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Signaling events mediated by PTP1B
|
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IL12-mediated signaling events
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S1P3 pathway
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SHP2 signaling
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
|
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Notch-mediated HES/HEY network
|
|
Reactome
|
Interleukin-6 signaling
|
|
MAPK3 (ERK1) activation
|
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MAPK1 (ERK2) activation
|
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GPVI-mediated activation cascade
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Prolactin receptor signaling
|
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RMTs methylate histone arginines
|
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G beta:gamma signalling through PI3Kgamma
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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RAF/MAP kinase cascade
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet production
|
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WikiPathways
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Serotonin Receptor 2 and STAT3 Signaling
|
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Type II interferon signaling (IFNG)
|
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Notch Signaling Pathway
|
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EPO Receptor Signaling
|
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EGF/EGFR Signaling Pathway
|
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IL-4 Signaling Pathway
|
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IL-6 signaling pathway
|
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Kit receptor signaling pathway
|
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IL-3 Signaling Pathway
|
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Mesodermal Commitment Pathway
|
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Interleukin-2 signaling
|
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Signaling by SCF-KIT
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Prolactin receptor signaling
|
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Growth hormone receptor signaling
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JAK/STAT
|
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
|
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TSLP Signaling Pathway
|
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IL17 signaling pathway
|
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Leptin signaling pathway
|
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TSH signaling pathway
|
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Interleukin-3, 5 and GM-CSF signaling
|
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Interferon gamma signaling
|
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Factors involved in megakaryocyte development and platelet production
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032732) |
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| REF 2 | Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders. Leukemia. 2008 Jul;22(7):1320-34. |
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