Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S1LA
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| Former ID |
DNC013535
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| Drug Name |
GFPTGG
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C24H34N6O8
|
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| Canonical SMILES |
CC(C(C(=O)NCC(=O)NCC(=O)O)NC(=O)C1CCCN1C(=O)C(CC2=CC=CC<br />=C2)NC(=O)CN)O
|
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| InChI |
1S/C24H34N6O8/c1-14(31)21(23(37)27-12-19(33)26-13-20(34)35)29-22(36)17-8-5-9-30(17)24(38)16(28-18(32)11-25)10-15-6-3-2-4-7-15/h2-4,6-7,14,16-17,21,31H,5,8-13,25H2,1H3,(H,26,33)(H,27,37)(H,28,32)(H,29,36)(H,34,35)/t14-,16+,17+,21+/m1/s1
|
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| InChIKey |
JWBSOWVZSDHJSP-IOFRSVQKSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | ||||
| Superpathway of cholesterol biosynthesis | |||||
| Mevalonate pathway | |||||
| KEGG Pathway | Terpenoid backbone biosynthesis | ||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| AMPK signaling pathway | |||||
| Bile secretion | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| TSH Signaling Pathway | |||||
| PANTHER Pathway | Cholesterol biosynthesis | ||||
| PathWhiz Pathway | Steroid Biosynthesis | ||||
| WikiPathways | Statin Pathway | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Activation of Gene Expression by SREBP (SREBF) | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| Integrated Breast Cancer Pathway | |||||
| SREBP signalling | |||||
| Cholesterol Biosynthesis | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2008 Feb 1;16(3):1309-18. Epub 2007 Oct 23.Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. | ||||
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