Drug General Information
Drug ID	D0S1VV
Former ID	DNC011237
Drug Name	7-methoxytacrine
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[545830]
Structure		Download 2D MOL 3D MOL
Formula	C14H16N2O
Canonical SMILES	COC1=CC2=C(C=C1)N=C3CCCCC3=C2N
InChI	1S/C14H16N2O/c1-17-9-6-7-13-11(8-9)14(15)10-4-2-3-5-12(10)16-13/h6-8H,2-5H2,1H3,(H2,15,16)
InChIKey	APQPVVOYBLOJDY-UHFFFAOYSA-N
PubChem Compound ID	119053
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[531150]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 545830	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004958)
Ref 531150	Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.

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