Drug General Information |
Drug ID |
D0S2OA
|
Former ID |
DNC007500
|
Drug Name |
1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
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2D MOL
3D MOL
|
Formula |
C31H31NO
|
Canonical SMILES |
C1CN(CCC1(C2=CC=CC=C2)OCC3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC<br />=CC=C5
|
InChI |
1S/C31H31NO/c1-5-13-26(14-6-1)25-33-31(29-19-11-4-12-20-29)21-23-32(24-22-31)30(27-15-7-2-8-16-27)28-17-9-3-10-18-28/h1-20,30H,21-25H2
|
InChIKey |
KSNUQMXXRSKFOM-UHFFFAOYSA-N
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PubChem Compound ID |
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Target and Pathway |
Target(s) |
Nociceptin receptor |
Target Info |
Inhibitor |
[1]
|
Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Opioid prodynorphin pathway
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Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
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WikiPathways
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signaling
|
References |
REF 1 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. |