Drug General Information
Drug ID	D0S3UH
Former ID	DIB002459
Drug Name	SUVN-507
Synonyms	M1 of SUVN-507, Suven; 5-HT 6 antagonist (cognitive disorder), Suven
Indication	Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10:I21, I22, R52, R52.1-R52.2, R60.9, G89]		Investigative	[543365]
Company	Suven Life Sciences Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1(cc(c2ccccc12)N1CCN(CC1)C)S(=O)(=O)c1ccc(cc1)C(C)C
Target and Pathway
Target(s)	5-hydroxytryptamine 6 receptor	Target Info	Antagonist	[543365]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543365	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).
Ref 543365	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11).

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