Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S3YP
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| Former ID |
DIB018210
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| Drug Name |
[3H](+)-isradipine
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| Synonyms |
(+)-[3H]isradipine; (+)-[3H]O5-methyl O3-propan-2-yl 4-(2,1,3-benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3H-(+)-PN 200-110
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
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Download2D MOL |
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| Formula |
C19H21N3O5
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| InChI |
InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3/t16-/m0/s1
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| InChIKey |
HMJIYCCIJYRONP-INIZCTEOSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Voltage-dependent L-type calcium channel alpha-1D subunit | Target Info | Inhibitor (gating inhibitor) | [2] | |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Target Info | Inhibitor (gating inhibitor) | [3] | ||
| Cav1.1 | Target Info | Inhibitor (gating inhibitor) | [4] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Calcium signaling pathway | |||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Cardiac muscle contraction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Circadian entrainment | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Cholinergic synapse | |||||
| Serotonergic synapse | |||||
| GABAergic synapse | |||||
| Dopaminergic synapse | |||||
| Insulin secretion | |||||
| GnRH signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Type II diabetes mellitus | |||||
| Carbohydrate digestion and absorption | |||||
| Alzheimer's disease | |||||
| Amphetamine addiction | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |||||
| Dilated cardiomyopathyhsa04010:MAPK signaling pathway | |||||
| Long-term potentiation | |||||
| Dilated cardiomyopathy | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| 5HT2 type receptor mediated signaling pathway | |||||
| Beta1 adrenergic receptor signaling pathway | |||||
| Beta2 adrenergic receptor signaling pathway | |||||
| Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway | |||||
| Oxytocin receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Adrenaline,noradrenaline inhibits insulin secretion | ||||
| NCAM1 interactions | |||||
| Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion | |||||
| Regulation of insulin secretion | |||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | ||||
| Arrhythmogenic Right Ventricular Cardiomyopathy | |||||
| Alzheimers Disease | |||||
| NCAM signaling for neurite out-growth | |||||
| Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell | |||||
| Integration of energy metabolism | |||||
| Nicotine Activity on Chromaffin Cells | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2733). | ||||
| REF 2 | Alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. J Biol Chem. 2001 Jun 22;276(25):22100-6. Epub 2001 Apr 2. | ||||
| REF 3 | Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest. 2004 May;113(10):1430-9. | ||||
| REF 4 | Biochemical characterization of plasma membrane isolated from human skeletal muscle. FEBS Lett. 1985 Sep 2;188(2):222-6. | ||||
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