Drug Information

Drug General Information
Drug ID
D0S5QB
Former ID
DNC003608
Drug Name
KYS-05040
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527099]
Structure
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2D MOL

3D MOL
Formula
C28H31N5O
Canonical SMILES
C1CCN(CC1)C2=NC3=CC=CC=C3C(N2C4=CC=CC=C4)CC(=O)NCC5=CC=<br />C(C=C5)N
InChI
1S/C28H31N5O/c29-22-15-13-21(14-16-22)20-30-27(34)19-26-24-11-5-6-12-25(24)31-28(32-17-7-2-8-18-32)33(26)23-9-3-1-4-10-23/h1,3-6,9-16,26H,2,7-8,17-20,29H2,(H,30,34)
InChIKey
NEMYASVJMUEWED-UHFFFAOYSA-N
PubChem Compound ID
44342044
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Inhibitor [527099]
Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [527099]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
Type II diabetes mellitushsa04010:MAPK signaling pathway
PANTHER Pathway Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin CellsWP2355:Corticotropin-releasing hormone
References
Ref 527099Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84.3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Ref 527099Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84.3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.

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