Drug Information
Drug General Information | |||||
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Drug ID |
D0S7HM
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Former ID |
DCL001071
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Drug Name |
ENMD-2076
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Drug Type |
Small molecular drug
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Company |
Entremed
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Structure |
Download2D MOL |
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Formula |
C21H25N7
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InChI |
InChI=1S/C21H25N7/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26)/b9-8+
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InChIKey |
BLQYVHBZHAISJM-CMDGGOBGSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Aurora kinase A | Target Info | Inhibitor | [537564] | |
KEGG Pathway | Oocyte meiosis | ||||
Pathway Interaction Database | Aurora B signaling | ||||
Signaling by Aurora kinases | |||||
Integrin-linked kinase signaling | |||||
PLK1 signaling events | |||||
Aurora A signaling | |||||
References | |||||
Ref 531311 | ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37. | ||||
Ref 542810 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7885). |
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