Drug General Information
Drug ID
D0S9VL
Former ID
DIB020352
Drug Name
MGS0039
Synonyms
MGS-0039; MGS 0039
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538873]
Structure
Download
2D MOL
Formula
C15H14Cl2FNO5
InChI
InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
InChIKey
LFAGGDAZZKUVKO-JAGWWQSPSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Antagonist [527175]
Metabotropic glutamate receptor 2 Target Info Antagonist [527175]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 538873(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1397).
Ref 527175Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. J Med Chem. 2004 Aug 26;47(18):4570-87.

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