Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SJ2Q
|
||||
| Former ID |
DNC006677
|
||||
| Drug Name |
OLEANOLIC_ACID
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C30H48O3
|
||||
| InChI |
InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
|
||||
| InChIKey |
MIJYXULNPSFWEK-GTOFXWBISA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
411432, 606099, 8140048, 8157593, 12013877, 14931343, 16612754, 22396103, 24898021, 26725302, 29204449, 29228987, 48483988, 49999299, 53253218, 53788193, 57326261, 57654491, 85297334, 92298723, 92465252, 92711005, 93576683, 96023600, 103324264, 104082596, 104323458, 118048745, 124558746, 124800067, 125312644, 126524541, 126631301, 126657657, 126664253, 128600272, 134343882, 134976838, 136353287, 137006891, 137186946, 142252735, 152090835, 162223020, 163614423, 164786710, 175267875, 175607979, 178100342, 179150511
|
||||
| Target and Pathway | |||||
| Target(s) | mRNA of Protein tyrosine phosphatase-1B | Target Info | Inhibitor | [2] | |
| Glycogen phosphorylase, muscle form | Target Info | Inhibitor | [3] | ||
| DNA polymerase | Target Info | Inhibitor | [4] | ||
| BioCyc Pathway | Glycogenolysis | ||||
| KEGG Pathway | Adherens junction | ||||
| Insulin signaling pathwayhsa00500:Starch and sucrose metabolism | |||||
| Metabolic pathways | |||||
| Insulin signaling pathway | |||||
| Glucagon signaling pathway | |||||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Pathway Interaction Database | Insulin Pathway | ||||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
| Signaling events mediated by PTP1B | |||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
| Signaling events mediated by TCPTP | |||||
| IGF1 pathway | |||||
| EGF receptor (ErbB1) signaling pathway | |||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| PDGFR-beta signaling pathway | |||||
| N-cadherin signaling events | |||||
| Reactome | Integrin alphaIIb beta3 signaling | ||||
| Regulation of IFNG signaling | |||||
| Regulation of IFNA signaling | |||||
| Growth hormone receptor signaling | |||||
| WikiPathways | Insulin Signaling | ||||
| Growth hormone receptor signaling | |||||
| Leptin signaling pathway | |||||
| Interferon gamma signaling | |||||
| Interferon alpha/beta signaling | |||||
| Integrin alphaIIb beta3 signalingWP500:Glycogen Metabolism | |||||
| Metabolism of carbohydrates | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3306). | ||||
| REF 2 | J Nat Prod. 2009 Sep;72(9):1620-6.Chemical Constituents of the Roots of Euphorbia micractina. | ||||
| REF 3 | J Med Chem. 2008 Jun 26;51(12):3540-54. Epub 2008 Jun 3.Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. | ||||
| REF 4 | J Nat Prod. 1999 Dec;62(12):1624-6.DNA polymerase beta inhibitors from Baeckea gunniana. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.