Drug Information

Drug General Information
Drug ID
D0SJ6E
Former ID
DNC007927
Drug Name
N,N-dimethyl-2-(1-tosyl-1H-indol-3-yl)ethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528630]
Structure
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2D MOL

3D MOL
Formula
C19H22N2O2S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=CC=CC=C32)CCN(C)C
InChI
1S/C19H22N2O2S/c1-15-8-10-17(11-9-15)24(22,23)21-14-16(12-13-20(2)3)18-6-4-5-7-19(18)21/h4-11,14H,12-13H2,1-3H3
InChIKey
RJGTUGOGNODPPC-UHFFFAOYSA-N
PubChem Compound ID
44438719
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [528630]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 528630Bioorg Med Chem Lett. 2007 Mar 15;17(6):1691-4. Epub 2007 Jan 4.Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors.
Ref 528630Bioorg Med Chem Lett. 2007 Mar 15;17(6):1691-4. Epub 2007 Jan 4.Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors.

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