TTD | Drug: D0SK3A

Drug General Information
Drug ID	D0SK3A
Former ID	DIB018973
Drug Name	BIIL 260
Synonyms	BIIL-260; BIIL260
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541344]
Structure		Download 2D MOL
Formula	C30H30N2O3
InChI	InChI=1S/C30H30N2O3/c1-30(2,24-8-12-26(33)13-9-24)25-10-16-28(17-11-25)35-20-22-5-3-4-21(18-22)19-34-27-14-6-23(7-15-27)29(31)32/h3-18,33H,19-20H2,1-2H3,(H3,31,32)
InChIKey	MBLJFKQACMILLC-UHFFFAOYSA-N
PubChem Compound ID	9956189
PubChem Substance ID	14931832, 24225420, 46052796, 47880128, 48253995, 79000185, 128571595, 140136970, 163642014, 178102775, 198986383, 230874508
Target and Pathway
Target(s)	Leukotriene B4 receptor 2	Target Info	Antagonist	[528578]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 541344	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6154).
Ref 528578	Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis. Ann Rheum Dis. 2007 May;66(5):628-32. Epub 2006 Dec 14.

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Drug Information