Drug Information

Drug General Information
Drug ID
D0SM3V
Former ID
DIB018465
Drug Name
12-hydroxyheptadecatrienoic acid
Synonyms
12S-HHTrE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541349]
Structure
Download
2D MOL
Formula
C17H28O3
InChI
InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1
InChIKey
KUKJHGXXZWHSBG-WBGSEQOASA-N
PubChem Compound ID
5283141
PubChem Substance ID
4266099, 11038777, 15393682, 24895472, 26754887, 39316555, 57358867, 76294458, 104046489, 113859208, 126530967, 135611088, 137142446, 162227458, 163312126, 178102780, 179205530, 227683706, 252325851, 252463840
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Agonist [529399]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 541349(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6159).
Ref 52939912(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med. 2008 Apr 14;205(4):759-66.

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