Drug Information

Drug General Information
Drug ID
D0SN7I
Former ID
DCL000387
Drug Name
SB-656933
Drug Type
Small molecular drug
Indication Cystic fibrosis; Chronic obstructive pulmonary disease [ICD9: 277.0, 490-492, 494-496; ICD10:E84, J40-J44, J47] Phase 2 [543172], [550966]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C17H17Cl2FN4O4S
InChI
InChI=1S/C17H17Cl2FN4O4S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24/h1-5,21,25H,6-9H2,(H2,22,23,26)
InChIKey
YQYFEGTYCUQBEI-UHFFFAOYSA-N
PubChem Compound ID
10479502
PubChem Substance ID
15503380, 22807731, 40607096, 78025584, 137696019, 162109039, 163335285, 163347357, 172232426, 198944793, 227759203, 243083204, 252166707
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [550963]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543172(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8499).
Ref 550966Clinical pipeline report, company report or official report of GlaxoSmithKline.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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