Drug Information

Drug General Information
Drug ID
D0SS4P
Former ID
DAP000249
Drug Name
Pirbuterol
Synonyms
Maxair; Pirbuterolum; Pyrbuterol; Pirbuterol acetate salt; CP 24315-1; Maxair (TN); Pirbuterol (INN); Pirbuterol [INN:BAN]; Pirbuterolum [INN-Latin]; CP-24315-1; CP-24,314-1; CP-24,314-14; 2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-tert-butylamino ethyl)pyridine, dihydrochloride; 2-tert-Butylamino-1-(5-hydroxy-6-hydroxymethyl-2-pyridyl)ethanol; 6-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)-3-pyridinol; 6-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-ol
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [536361], [542292]
Therapeutic Class
Bronchodilator Agents
Company
3M Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C12H20N2O3
InChI
InChI=1S/C12H20N2O3/c1-12(2,3)13-6-11(17)8-4-5-10(16)9(7-15)14-8/h4-5,11,13,15-17H,6-7H2,1-3H3
InChIKey
VQDBNKDJNJQRDG-UHFFFAOYSA-N
CAS Number
CAS 38677-81-5
PubChem Compound ID
4845
PubChem Substance ID
10009, 5518522, 8152979, 10320223, 11407589, 15196418, 29223926, 46506379, 49967589, 57322484, 80738546, 85220239, 96025073, 103749740, 104307595, 125679197, 129511004, 134221951, 134337563, 135001188, 137054085, 137619489, 160964608, 163078219, 172873513, 178103846, 179150409, 223440681, 224856379, 226396743, 241067986
SuperDrug ATC ID
R03AC08; R03CC07
SuperDrug CAS ID
cas=038677815
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [536347], [536442]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542292(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7272).
Ref 536347A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. Oncogene. 2007 May 31;26(26):3777-88. Epub 2007 Jan 29.
Ref 536442Inhaled beta agonists. Respir Care. 2007 Jul;52(7):820-32.

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