Drug Information

Drug General Information
Drug ID
D0T0LM
Former ID
DAP000492
Drug Name
Pirenzepine
Synonyms
Gasteril; Gastrotsepin; Gastrozepin; Pirenzepin; Pirenzepina; Pirenzepinum; Pyrenzepine; Ulcosan; Pirenzepine Gastrozepin; Gastrozepin (TN); L-S 519; Pirenzepina [INN-Spanish]; Pirenzepine (INN); Pirenzepine [INN:BAN]; Pirenzepinum [INN-Latin]; 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one; 5,11-Dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one
Drug Type
Small molecular drug
Indication Peptic ulcer [ICD9: 531-534; ICD10:K25-K27] Approved [535729], [540243]
Therapeutic Class
Antiulcer Agents
Company
Boehringer Ingelheim
Structure
Download
2D MOL

3D MOL
Formula
C19H21N5O2
InChI
InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
InChIKey
RMHMFHUVIITRHF-UHFFFAOYSA-N
CAS Number
CAS 28797-61-7
PubChem Compound ID
4848
PubChem Substance ID
9711, 5518525, 7980332, 8152981, 11111661, 11111662, 11113363, 11335302, 11360541, 11364272, 11366834, 11369396, 11372544, 11373933, 11377558, 11461513, 11466157, 11467277, 11485230, 11485853, 11489233, 11491268, 11492252, 11495192, 14852009, 26751604, 29223929, 46509029, 47211770, 47216642, 47365035, 47365036, 47515172, 47588849, 47959578, 47959579, 48110309, 48334341, 48416446, 49698919, 50034085, 50100327, 50104261, 50139450, 50423922, 57322487, 81065495, 81093320, 85209239, 85787888
ChEBI ID
ChEBI:8247
SuperDrug ATC ID
A02BX03
SuperDrug CAS ID
cas=028797617
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Antagonist [535794], [537295]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 535729Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. J Cardiovasc Pharmacol. 2003 May;41(5):671-7.
Ref 540243(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 328).
Ref 535794The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma. Pneumonol Alergol Pol. 1992;60(11-12):32-6.
Ref 537295Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31. Epub 2009 May7.

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