Drug General Information
Drug ID	D0T2UB
Former ID	DIB010228
Drug Name	APCK-110
Synonyms	APCK-110; APcK-110MD; C-Kit inhibitors (cancer); C-Kit inhibitors (cancer), MD Anderson
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543493]
Company	MD Anderson Cancer Center
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(nc2c(c1)c(n[nH]2)c1ccc(c(c1)C)F)c1cc(cc(c1)OC)OC
Target and Pathway
Target(s)	Mast/stem cell growth factor receptor	Target Info	Inhibitor	[543493]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Hematopoietic cell lineage
	Melanogenesis
	Pathways in cancer
	Acute myeloid leukemia
	Central carbon metabolism in cancer
NetPath Pathway	IL3 Signaling Pathway
	IL4 Signaling Pathway
	KitReceptor Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
	Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome	PIP3 activates AKT signaling
	Regulation of KIT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascade
WikiPathways	Kit receptor signaling pathway
	Differentiation Pathway
	Signaling by SCF-KIT
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
References
Ref 543493	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1805).
Ref 543493	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1805).

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