Drug Information

Drug General Information
Drug ID
D0T4MJ
Former ID
DIB021001
Drug Name
K00592a
Synonyms
K00592a
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527614]
Structure
Download
2D MOL
Formula
C14H15F3N6O
InChI
InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)
InChIKey
FQNFLNSVHWCZML-UHFFFAOYSA-N
PubChem Compound ID
9549296
PubChem Substance ID
14720362, 16415215, 23984868, 44692625, 51550025, 103595701, 104103646, 127885148, 137087818, 178102669, 180372413, 227455471
Target and Pathway
Target(s) Tyrosine-protein kinase SYK Target Info Inhibitor [527614]
Zap70 tyrosine kinase Target Info Inhibitor [527614]
KEGG Pathway NF-kappa B signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
Epstein-Barr virus infection
Viral carcinogenesishsa04014:Ras signaling pathway
T cell receptor signaling pathway
Primary immunodeficiency
PANTHER Pathway B cell activationP00053:T cell activation
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
GMCSF-mediated signaling events
Atypical NF-kappaB pathway
Osteopontin-mediated events
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
IL2-mediated signaling events
Class I PI3K signaling events
Alpha-synuclein signalingtcr_pathway:TCR signaling in na&#xef
TCR signaling in na&#xef
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Integrin alphaIIb beta3 signaling
Interleukin-2 signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-202430:Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
WikiPathways IL-2 Signaling Pathway
IL-3 Signaling Pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Interleukin-2 signaling
Fcgamma receptor (FCGR) dependent phagocytosis
DAP12 interactions
B Cell Receptor Signaling Pathway
RANKL/RANK Signaling Pathway
Integrin alphaIIb beta3 signaling
GPVI-mediated activation cascade
Regulation of toll-like receptor signaling pathway
IL-5 Signaling PathwayWP69:TCR Signaling Pathway
Interferon type I signaling pathways
Inflammatory Response Pathway
JAK/STAT
T-Cell Receptor and Co-stimulatory Signaling
TCR signaling
References
Ref 527614Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.
Ref 527614Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.

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