TTD | Drug: D0T7GC

Drug General Information
Drug ID	D0T7GC
Former ID	DIB020777
Drug Name	Pyr3
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[467632]
Structure		Download 2D MOL
Formula	C16H11Cl3F3N3O3
InChI	InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey	RZHGONNSASQOAY-UHFFFAOYSA-N
PubChem Compound ID	56964346
PubChem Substance ID	135678761, 162249927, 163123003, 178101110, 204361136, 237363704, 241376620, 242817147, 249617973, 252157507, 252451316
Target and Pathway
Target(s)	Short transient receptor potential channel 3	Target Info	Blocker (channel blocker)	[530024]
Pathway Interaction Database	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	Effects of PIP2 hydrolysis
	TRP channels
	Role of second messengers in netrin-1 signaling
WikiPathways	Platelet homeostasis
	Netrin-1 signaling
	GPCR downstream signaling
	Effects of PIP2 hydrolysis
References
Ref 467632	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4293).
Ref 530024	Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.

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Drug Information