Drug General Information
Drug ID	D0T7RY
Former ID	DNC008398
Drug Name	6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529221]
Structure		Download 2D MOL 3D MOL
Formula	C10H11Cl2N
Canonical SMILES	C1CNCCC2=C1C=CC(=C2Cl)Cl
InChI	1S/C10H11Cl2N/c11-9-2-1-7-3-5-13-6-4-8(7)10(9)12/h1-2,13H,3-6H2
InChIKey	WMCWIMZEYWNBOQ-UHFFFAOYSA-N
PubChem Compound ID	9813197
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Inhibitor	[529221]
	5-hydroxytryptamine 2B receptor	Target Info	Inhibitor	[529221]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[529221]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, Other
References
Ref 529221	Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. Epub 2007 Dec 8.Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.
Ref 529221	Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. Epub 2007 Dec 8.Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.

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