Drug Information

Drug General Information
Drug ID
D0T7VZ
Former ID
DNC005276
Drug Name
2-(1-benzyl-1H-indol-3-yl)-N,N-dimethylethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529929]
Structure
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2D MOL

3D MOL
Formula
C19H22N2
Canonical SMILES
CN(C)CCC1=CN(C2=CC=CC=C21)CC3=CC=CC=C3
InChI
1S/C19H22N2/c1-20(2)13-12-17-15-21(14-16-8-4-3-5-9-16)19-11-7-6-10-18(17)19/h3-11,15H,12-14H2,1-2H3
InChIKey
QBWKAYAFIXQNCU-UHFFFAOYSA-N
PubChem Compound ID
44397102
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529929]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529929J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.
Ref 529929J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.

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