Drug General Information
Drug ID	D0T8UR
Former ID	DNC005859
Drug Name	3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527668]
Structure		Download 2D MOL 3D MOL
Formula	C12H16N2O
Canonical SMILES	CN1C=C(C2=C1C=CC=C2O)CN(C)C
InChI	1S/C12H16N2O/c1-13(2)7-9-8-14(3)10-5-4-6-11(15)12(9)10/h4-6,8,15H,7H2,1-3H3
InChIKey	QOWUCENJFGRMQC-UHFFFAOYSA-N
PubChem Compound ID	44404904
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Inhibitor	[527668]
	5-hydroxytryptamine 2B receptor	Target Info	Inhibitor	[527668]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[527668]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, Other
References
Ref 527668	Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Ref 527668	Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9.SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.

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