Drug Information

Drug General Information
Drug ID
D0T9TJ
Former ID
DAP000053
Drug Name
Orlistat
Synonyms
Alli; Orlipastat; Orlipastatum; THLP; Tetrahydrolipstatin; Xenical; GlaxoSmithKline brand of orlistat; Roche brand of orlistat; Alli (TN); Hoffmann-La Roche brand of orlistat; KS-1183; Orlipastatum [INN-Latin]; Orlistat [USAN:INN]; R-212; Xenical (TN); Orlistat (USAN/INN); Ro 18-0647/002; Ro 18-0647/008; Ro-18-0647; Alli, Xenical, Tetrahydrolipstatin, Orlistat; N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; N-Formyl-L-leucine, ester with (3S,4S)-3-hexyl-4-((2S)-2-hydroxytridecyl)-2-oxetanone; L-Leucine, N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; L-Leucine,N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate; (-)-Tetrahydrolipstatin; 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Approved [535886], [540740]
Therapeutic Class
Antiobesity Agents
Company
GlaxoSmithKline plc
Structure
Download
2D MOL

3D MOL
Formula
C29H53NO5
InChI
InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
InChIKey
AHLBNYSZXLDEJQ-FWEHEUNISA-N
CAS Number
CAS 96829-58-2
PubChem Compound ID
3034010
PubChem Substance ID
7980207, 10047880, 11528795, 12013644, 14810727, 14933128, 17398010, 24724564, 26719846, 29217614, 36077810, 46386654, 46508309, 49681644, 51044514, 56269518, 56365491, 57352838, 92308398, 92717140, 93167011, 93576635, 93815140, 103436517, 104253266, 111635568, 117682959, 118048581, 124658856, 124757388, 124893192, 125164192, 125268639, 125311705, 126592933, 126622459, 126670765, 127407306, 134337381, 134346495, 134358631, 135027708, 135727048, 136023849, 136946428, 137001362, 143126586, 143495309, 144116319, 152034294
SuperDrug ATC ID
A08AB01
SuperDrug CAS ID
cas=096829582
Target and Pathway
Target(s) Triacylglycerol lipase, pancreatic Target Info Modulator [556264]
BioCyc Pathway Triacylglycerol degradation
Retinol biosynthesis
KEGG Pathway Glycerolipid metabolism
Metabolic pathways
Pancreatic secretion
Fat digestion and absorption
Vitamin digestion and absorption
Reactome Retinoid metabolism and transport
WikiPathways Visual phototransduction
Lipid digestion, mobilization, and transport
References
Ref 535886Obesity and pharmacologic therapy. Endocrinol Metab Clin North Am. 2003 Dec;32(4):1005-24.
Ref 540740(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5277).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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