Drug General Information
Drug ID	D0TK0W
Former ID	DIB010295
Drug Name	Ro-46-5934
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[533753]
Company	F Hoffmann-La Roche Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(Oc1c2c([C@@H]3[C@@H](N(CC3)CCC3CCCCC3)CC2)ccc1)N(<br />C)C
CAS Number	CAS 158182-74-2
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[533753]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 533753	A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.
Ref 533753	A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.

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