Drug General Information
Drug ID	D0TM4K
Former ID	DNC005633
Drug Name	3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527456]
Structure		Download 2D MOL 3D MOL
Formula	C16H15N
Canonical SMILES	CC1CC(=CC2=CN=CC=C2)C3=CC=CC=C13
InChI	1S/C16H15N/c1-12-9-14(10-13-5-4-8-17-11-13)16-7-3-2-6-15(12)16/h2-8,10-12H,9H2,1H3/b14-10+
InChIKey	KMRIBBKLCIMDTB-GXDHUFHOSA-N
PubChem Compound ID	6539817
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[527456]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 527456	J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
Ref 527456	J Med Chem. 2005 Mar 10;48(5):1563-75.Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.

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