Drug Information

Drug General Information
Drug ID
D0U1OM
Former ID
DAP000732
Drug Name
Bromfenac
Synonyms
Bromfenaco; Bromfenacum; Duract; Xibrom; BROMFENAC SODIUM; Bromfenac [INN]; Bromfenaco [Spanish]; Bromfenacum [Latin]; AHR-10282; Bromfenac (INN); Duract (TN); Xibrom (TN); Sodium 2-amino-3-(4-bromobenzoyl) phenylacetate sesquihydrate; [2-amino-3-(4-bromobenzoyl)phenyl]acetic acid; {2-amino-3-[(4-bromophenyl)carbonyl]phenyl}acetic acid; [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid; 2-Amino-3-(4-bromobenzoyl)benzeneacetic acid; 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
Drug Type
Small molecular drug
Indication Postoperative inflammation [ICD9: 998; ICD10:T81] Approved [538571], [542138]
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Withdrawn from market [542138], [551871]
Therapeutic Class
Antiinflammatory Agents
Structure
Download
2D MOL

3D MOL
Formula
C15H12BrNO3
InChI
InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19)
InChIKey
ZBPLOVFIXSTCRZ-UHFFFAOYSA-N
CAS Number
CAS 91714-94-2
PubChem Compound ID
60726
PubChem Substance ID
8187024, 14802056, 43118081, 46508121, 50065379, 50714597, 51091863, 53786963, 57288753, 57314080, 85433311, 103293849, 104321485, 117562408, 119526091, 125536482, 129879365, 131330262, 134338019, 135065652, 137005805, 142970983, 152227509, 160814551, 160964302, 162197012, 163089933, 163373042, 163837609, 164117525, 164175212, 172092503, 175268177, 178103707, 179151433, 184545820, 186004941, 196396861, 203081294, 204420653, 223388494, 223435566, 223484710, 223551046, 223656326, 224730616, 226420876, 242065764, 249847324, 250181405
SuperDrug ATC ID
S01BC11
Target and Pathway
Target(s) Prostaglandin G/H synthase 1 Target Info Inhibitor [536249]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 538571FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021664.
Ref 542138(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7131).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536249Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40.

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