Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D0U4EU
|
||||
Former ID |
DCL000224
|
||||
Drug Name |
SB-743921
|
||||
Synonyms |
N-[1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)propyl]-4-bromo-N-(3-dimethylaminopropyl)benzamide
|
||||
Drug Type |
Small molecular drug
|
||||
Therapeutic Class |
Anticancer Agents
|
||||
Company |
GlaxoSmithKline
|
||||
Structure |
Download2D MOL |
||||
Formula |
C30H32BrClN4O2
|
||||
Canonical SMILES |
CCC(C1=NC2=C(C=CC(=C2)Cl)C(=O)N1CC3=CC=CC=C3)N(CCCN(C)C<br />)C(=O)C4=CC=C(C=C4)Br
|
||||
InChI |
1S/C30H32BrClN4O2/c1-4-27(35(18-8-17-34(2)3)29(37)22-11-13-23(31)14-12-22)28-33-26-19-24(32)15-16-25(26)30(38)36(28)20-21-9-6-5-7-10-21/h5-7,9-16,19,27H,4,8,17-18,20H2,1-3H3
|
||||
InChIKey |
PZVLDHUUSWUATQ-UHFFFAOYSA-N
|
||||
PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Kinesin-like protein KIF11 | Target Info | Inhibitor | [537212] | |
WikiPathways | MHC class II antigen presentation | ||||
Kinesins | |||||
References | |||||
Ref 521846 | ClinicalTrials.gov (NCT00343564) A Study of SB-743921 in Non-Hodgkin's Lymphoma. U.S. National Institutes of Health. | ||||
Ref 530907 | A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.