Drug Information
Drug General Information | |||||
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Drug ID |
D0U5NU
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Former ID |
DIB016533
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Drug Name |
GLENVASTATIN
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Synonyms |
HR-780; Glenvastatin < Rec INN >; [4(R),6(S),(E)]-6-[2-[4-(4-Fluorophenyl)-2-isopropyl-6-phenyl-3-pyridyl]vinyl]-4-hydroxytetrahydropyran-2-one
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Drug Type |
Small molecular drug
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Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Discontinued in Phase 2 | [544823] | ||
Structure |
Download2D MOL |
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Formula |
C27H26FNO3
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Canonical SMILES |
CC(C)c1nc(cc(c1\\C=C\\[C@H]2C[C@H](O)CC(=O)O2)c3ccc(F)c<br />c3)c4ccccc4
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InChI |
1S/C27H26FNO3/c1-17(2)27-23(13-12-22-14-21(30)15-26(31)32-22)24(18-8-10-20(28)11-9-18)16-25(29-27)19-6-4-3-5-7-19/h3-13,16-17,21-22,30H,14-15H2,1-2H3/b13-12+/t21-,22-/m0/s1
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InChIKey |
LJIZUXQINHXGAO-WYCPQIHASA-N
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CAS Number |
CAS 122254-45-9
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Target Info | Inhibitor | [533833], [551871] | |
PANTHER Pathway | Cholesterol biosynthesis | ||||
PathWhiz Pathway | Steroid Biosynthesis | ||||
References |
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