| Drug General Information |
| Drug ID |
D0U6ZT
|
| Former ID |
DNC002573
|
| Drug Name |
3-Bromo-7-Nitroindazole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H4BrN3O2
|
| InChI |
InChI=1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
|
| InChIKey |
NFSTZPMYAZRZPC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
826437, 3153161, 5674219, 7888405, 8007079, 8007092, 11110834, 11113670, 11120304, 11120792, 11121280, 11121567, 11122047, 11362636, 11365198, 11367760, 11370543, 11370544, 11373361, 11375922, 14774073, 17404724, 24278258, 26612743, 26747128, 26751855, 26751856, 29220853, 46507791, 47440018, 47440019, 47662058, 47736239, 48259001, 48259002, 48628407, 50104555, 50104556, 50104557, 50104558, 52824169, 53777267, 57320966, 71822505, 81060425, 85230935, 85787746, 85789452, 88727144, 90341482
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[2]
|
|---|
| Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[2]
|
| Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[2]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
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KEGG Pathway
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Arginine and proline metabolism
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Metabolic pathways
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Platelet activation
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Estrogen signaling pathway
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Oxytocin signaling pathwayhsa00330:Arginine and proline metabolism
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Phagosome
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Circadian entrainment
|
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Long-term depression
|
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Salivary secretion
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
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Peroxisome
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
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Pathways in cancer
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Small cell lung cancer
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NetPath Pathway
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Wnt Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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VEGF signaling pathwayP06959:CCKR signaling map ST
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling eventsil12_2pathway:IL12-mediated signaling events
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Alpha9 beta1 integrin signaling events
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ATF-2 transcription factor network
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IL23-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Arginine and Proline Metabolism
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Reactome
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ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeabilityR-HSA-1222556:ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
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WikiPathways
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ACE Inhibitor Pathway
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EGF/EGFR Signaling Pathway
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Myometrial Relaxation and Contraction Pathways
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JAK/STAT
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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Endothelin Pathways
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Leptin signaling pathway
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Effects of Nitric Oxide
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Metabolism of nitric oxide
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AngiogenesisWP727:Monoamine Transport
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Amyotrophic lateral sclerosis (ALS)
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Alzheimers Disease
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Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5113). |
|---|
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
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