Drug General Information
Drug ID	D0U7BH
Former ID	DIB018070
Drug Name	(+)-norfenfluramine
Synonyms	(S)-norfenfluramine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539369]
Structure		Download 2D MOL
Formula	C10H12F3N
InChI	InChI=1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3/t7-/m0/s1
InChIKey	MLBHFBKZUPLWBD-ZETCQYMHSA-N
PubChem Compound ID	9815618
PubChem Substance ID	14773143, 15171751, 24120289, 44851589, 47880078, 48105163, 48179702, 48253938, 48253939, 50076580, 80908839, 90340920, 103556029, 128611224, 135650733, 135696251, 136351630, 139972395, 162808682, 177749796, 230574337
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Agonist	[525929]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539369	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 216).
Ref 525929	Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41.

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