Drug Information

Drug General Information
Drug ID
D0UB6O
Former ID
DNC000022
Drug Name
[125I]SB-258585
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540218]
Structure
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2D MOL

3D MOL
Formula
C18H22IN3O3S
InChI
InChI=1S/C18H22IN3O3S/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16/h3-8,13,20H,9-12H2,1-2H3/i19-2
InChIKey
BDHMSYNBSBZCAF-GBVACIEGSA-N
CAS Number
CAS 1071-83-6
PubChem Compound ID
10743500
PubChem Substance ID
15779828, 23018499, 77817170, 124974659, 141679208, 178100294, 239100054, 248867482
ChEBI ID
ChEBI:27744
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [535506]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540218(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3245).
Ref 5355065-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. Synapse. 2002 Sep 1;45(3):191-9.

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