Drug General Information
Drug ID
D0UL7R
Former ID
DIB020952
Drug Name
SKA-31
Synonyms
2-aminonaphthiazole; 2-amino-beta-naphthothiazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539479]
Structure
Download
2D MOL
Formula
C11H8N2S
InChI
InChI=1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChIKey
FECQXVPRUCCUIL-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) KCa3.1 Target Info Activator [529778]
References
Ref 539479(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2335).
Ref 529778Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95.

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