Drug Information
Drug General Information | |||||
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Drug ID |
D0UO1E
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Former ID |
DNC005942
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Drug Name |
Para-sirtinol
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
Download2D MOL |
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Formula |
C26H22N2O2
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Canonical SMILES |
CC(C1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)NC=C3C(=O)C=CC4=CC=CC<br />=C43
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InChI |
1S/C26H22N2O2/c1-18(19-7-3-2-4-8-19)28-26(30)21-11-14-22(15-12-21)27-17-24-23-10-6-5-9-20(23)13-16-25(24)29/h2-18,27H,1H3,(H,28,30)/b24-17-
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InChIKey |
COIQVEAHCAAJDH-ULJHMMPZSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | NAD-dependent deacetylase sirtuin-1 | Target Info | Inhibitor | [1] | |
KEGG Pathway | FoxO signaling pathway | ||||
AMPK signaling pathway | |||||
Glucagon signaling pathway | |||||
Amphetamine addiction | |||||
MicroRNAs in cancer | |||||
PANTHER Pathway | p53 pathway | ||||
Pathway Interaction Database | p73 transcription factor network | ||||
Signaling events mediated by HDAC Class III | |||||
E2F transcription factor network | |||||
HIF-2-alpha transcription factor network | |||||
Signaling events mediated by HDAC Class I | |||||
FoxO family signaling | |||||
Regulation of Androgen receptor activity | |||||
Regulation of retinoblastoma protein | |||||
Reactome | RORA activates gene expression | ||||
Regulation of HSF1-mediated heat shock response | |||||
Circadian Clock | |||||
WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
SREBF and miR33 in cholesterol and lipid homeostasis | |||||
Integrated Breast Cancer Pathway | |||||
SREBP signalling | |||||
Androgen receptor signaling pathway | |||||
References | |||||
REF 1 | J Med Chem. 2005 Dec 1;48(24):7789-95.Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. | ||||
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