Drug Information

Drug General Information
Drug ID
D0UO9T
Former ID
DIB004758
Drug Name
VR-147
Synonyms
Migraine therapeutic, Vectura; Migraine therapy, Vectura; Triptan (inhaled, migraine), Vectura
Indication Migraine [ICD9: 346; ICD10:G43] Terminated [548264]
Company
Vectura Group plc
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Modulator [550903], [551730]
5-hydroxytryptamine 1B receptor Target Info Modulator [550903], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 548264Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023937)
Ref 550903US patent application no. 2010,0112,050, Dosage form for insertion into the mouth.
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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