Drug Information

Drug General Information
Drug ID
D0V0JR
Former ID
DIB016417
Drug Name
Cadi-05
Synonyms
Mycobacterium w; Poly-TLR agonist polyantigenic vaccine (cancer), Cadila; Poly-toll-like receptor agonist polyantigenic vaccine (cancer), Cadila
Drug Type
Vaccine
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 3 [522525]
Company
Cadila Pharmaceuticals Ltd
Target and Pathway
Target(s) Toll-like receptor 9 Target Info [544251]
Toll-like receptor 2 Target Info [544251]
Toll-like receptor 4 Target Info [544251]
KEGG Pathway Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Measles
Herpes simplex infectionhsa04145:Phagosome
PI3K-Akt signaling pathway
Legionellosis
Leishmaniasis
Toxoplasmosis
Amoebiasis
Hepatitis B
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritishsa04064:NF-kappa B signaling pathway
HIF-1 signaling pathway
Phagosome
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Influenza A
Rheumatoid arthritis
NetPath Pathway BCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signalingtoll_endogenous_pathway:Endogenous TLR signaling
Reactome PI3K Cascade
Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosomeR-HSA-1461957:Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)R-HSA-140534:Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR3/TLR4 cascade
TRIF-mediated programmed cell death
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complex
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
MyD88:Mal cascade initiated on plasma membrane
Defensins
MyD88-independent cascade
Primary Focal Segmental Glomerulosclerosis FSGS
Spinal Cord Injury
Corticotropin-releasing hormone
Pathogenic Escherichia coli infection
Regulation of toll-like receptor signaling pathway
References
Ref 522525ClinicalTrials.gov (NCT00810849) A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis. U.S. National Institutes of Health.
Ref 544251Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.

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