Drug Information
Drug General Information | |||||
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Drug ID |
D0V0LU
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Former ID |
DNC008196
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Drug Name |
Ohioensin C
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C24H18O5
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Canonical SMILES |
COC1=CC(=C2C(=O)CC3C4C2=C1C5=C(C4OC6=CC=CC=C36)C=CC=C5O<br />)O
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InChI |
1S/C24H18O5/c1-28-18-10-16(27)21-15(26)9-13-11-5-2-3-8-17(11)29-24-12-6-4-7-14(25)19(12)22(18)23(21)20(13)24/h2-8,10,13,20,24-25,27H,9H2,1H3/t13-,20+,24+/m1/s1
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InChIKey |
ZVFNSNHXUYAPTP-VVTWNTARSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | mRNA of Protein tyrosine phosphatase-1B | Target Info | Inhibitor | [1] | |
KEGG Pathway | Adherens junction | ||||
Insulin signaling pathway | |||||
NetPath Pathway | FSH Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
Pathway Interaction Database | Insulin Pathway | ||||
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
Signaling events mediated by PTP1B | |||||
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
Signaling events mediated by TCPTP | |||||
IGF1 pathway | |||||
EGF receptor (ErbB1) signaling pathway | |||||
Posttranslational regulation of adherens junction stability and dissassembly | |||||
PDGFR-beta signaling pathway | |||||
N-cadherin signaling events | |||||
Reactome | Integrin alphaIIb beta3 signaling | ||||
Regulation of IFNG signaling | |||||
Regulation of IFNA signaling | |||||
Growth hormone receptor signaling | |||||
WikiPathways | Insulin Signaling | ||||
Growth hormone receptor signaling | |||||
Leptin signaling pathway | |||||
Interferon gamma signaling | |||||
Interferon alpha/beta signaling | |||||
Integrin alphaIIb beta3 signaling | |||||
References | |||||
REF 1 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. Epub 2007 Nov 17.Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. | ||||
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