Drug General Information
Drug ID	D0V3HG
Former ID	DNC000488
Drug Name	CV-6504
Drug Type	Small molecular drug
Indication	Discovery agent		Discontinued in Phase 2	[1]
Structure		Download 2D MOL 3D MOL
Formula	C15H15NO2
Canonical SMILES	CC1=C(C(=O)C(=C(C1=O)C)CC2=CN=CC=C2)C
InChI	1S/C15H15NO2/c1-9-10(2)15(18)13(11(3)14(9)17)7-12-5-4-6-16-8-12/h4-6,8H,7H2,1-3H3
InChIKey	IPGAFOVEIIWXFR-UHFFFAOYSA-N
CAS Number	CAS 117574-40-0
PubChem Compound ID	93543
PubChem Substance ID	10226050, 14749588, 44424262, 57335664, 77704089, 81065591, 103283006, 104410405, 125710320, 128200574, 134339900, 135050450, 137053258, 140348626, 162378108, 162778655, 228801628
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[2], [3]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
REF 1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003054)
REF 2	A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann Oncol. 2000 Sep;11(9):1165-70.
REF 3	Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats. Kidney Int. 1991 May;39(5):920-9.

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