Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V3IT
|
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| Former ID |
DNC004177
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| Drug Name |
SNAP-5150
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C36H41N5O4
|
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| Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)NCCCCN2CCC(CC2)(C3=CC=CC=C3)C4=C<br />C=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
|
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| InChI |
1S/C36H41N5O4/c1-25-31(34(37)42)33(27-15-17-30(18-16-27)41(44)45)32(26(2)39-25)35(43)38-21-9-10-22-40-23-19-36(20-24-40,28-11-5-3-6-12-28)29-13-7-4-8-14-29/h3-8,11-18,33,39H,9-10,19-24H2,1-2H3,(H2,37,42)(H,38,43)/t33-/m0/s1
|
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| InChIKey |
RJEWWPFKTYWTSS-XIFFEERXSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Inhibitor | [1] | |
| Alpha-2B adrenergic receptor | Target Info | Inhibitor | [1] | ||
| Alpha-2A adrenergic receptor | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolismR-HSA-390696:Adrenoceptors | |||||
| G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors | |||||
| Surfactant metabolism | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP58:Monoamine GPCRs | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.Design and synthesis of novel dihydropyridine alpha-1a antagonists. | ||||
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