Drug Information
Drug General Information | |||||
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Drug ID |
D0V3IT
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Former ID |
DNC004177
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Drug Name |
SNAP-5150
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C36H41N5O4
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Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)NCCCCN2CCC(CC2)(C3=CC=CC=C3)C4=C<br />C=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
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InChI |
1S/C36H41N5O4/c1-25-31(34(37)42)33(27-15-17-30(18-16-27)41(44)45)32(26(2)39-25)35(43)38-21-9-10-22-40-23-19-36(20-24-40,28-11-5-3-6-12-28)29-13-7-4-8-14-29/h3-8,11-18,33,39H,9-10,19-24H2,1-2H3,(H2,37,42)(H,38,43)/t33-/m0/s1
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InChIKey |
RJEWWPFKTYWTSS-XIFFEERXSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Alpha-2C adrenergic receptor | Target Info | Inhibitor | [1] | |
Alpha-2B adrenergic receptor | Target Info | Inhibitor | [1] | ||
Alpha-2A adrenergic receptor | Target Info | Inhibitor | [1] | ||
KEGG Pathway | cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway | |||||
Reactome | Adrenoceptors | ||||
Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
Adrenaline,noradrenaline inhibits insulin secretion | |||||
G alpha (i) signalling events | |||||
G alpha (z) signalling events | |||||
Surfactant metabolismR-HSA-390696:Adrenoceptors | |||||
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors | |||||
Surfactant metabolism | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Platelet Aggregation (Plug Formation) | |||||
Integration of energy metabolism | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP58:Monoamine GPCRs | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.Design and synthesis of novel dihydropyridine alpha-1a antagonists. | ||||
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